Abstract
We assessed the circulation of severe acute respiratory syndrome coronavirus-2 variants amongst vaccinated military personnel in Bogotá, Colombia to evaluate the mutations of certain variants and their potential for breakthrough infection in vaccinated subjects. We observed that in vaccinated individuals the most frequent infecting lineage was Mu (B.1.621 and B.1.621.1). The above is possibly associated with specific mutations that confer it with vaccine-induced immune escape ability. Our findings highlight the importance of how genomic tracking coupled with epidemiological surveillance can assist in the study of novel emerging variants (e.g., Omicron) and their impact on vaccination efforts worldwide.
Keywords: RT-PCR; SARS-CoV-2; sequencing; variants.
【저자키워드】 SARS-CoV-2, Sequencing, RT-PCR, variants., 【초록키워드】 vaccination, Mutation, Sequencing, variant, severe acute respiratory syndrome Coronavirus, omicron, RT-PCR, variants, Severe acute respiratory syndrome, Surveillance, Immune escape, Lineage, epidemiological, Breakthrough infection, epidemiological surveillance, circulation, respiratory, genomic, B.1.621, Coronavirus-2, acute respiratory syndrome, acute respiratory syndrome coronavirus, acute respiratory syndrome coronavirus-2, effort, specific mutations, vaccinated individuals, vaccinated individual, infecting, highlight, evaluate, subjects, assist, specific mutation, 【제목키워드】 Vaccine, variant, Impact, genomics study,