Abstract
In less than eleven months, the world was brought to a halt by the COVID-19 outbreak. With hospitals becoming overwhelmed, one of the highest priorities concerned critical care triage to ration the scarce resources of intensive care units. Which patient should be treated first? Based on what clinical and biological criteria? A global joint effort rapidly led to sequencing the genomes of tens of thousands of COVID-19 patients to determine the patients’ genetic signature that causes them to be at risk of suddenly developing severe disease. In this commentary, we would like to consider some points concerning the use of a multifactorial risk score for COVID-19 severity. This score includes macroautophagy (hereafter referred to as autophagy), a critical host process that controls all steps harnessed by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus. Abbreviation list: ATG5: autophagy related 5; BECN1: beclin 1; COVID-19: coronavirus infectious disease-2019; EGR1: early growth response 1; ER: endoplasmic reticulum; DMVs: double-membrane vesicles; IBV: infectious bronchitis virus; MAP1LC3: microtubule associated protein 1 light chain 3; LC3-I: proteolytically processed, non-lipidated MAP1LC3; LC3-II: lipidated MAP1LC3; MEFs: mouse embryonic fibroblasts; MERS-CoV: Middle East respiratory syndrome-coronavirus; MHV: mouse hepatitis virus; NSP: non-structural protein; PEDV: porcine epidemic diarrhea virus; PLP2-TM: membrane-associated papain-like protease 2; SARS-CoV-2: severe acute respiratory syndrome coronavirus 2; TGEV: transmissible gastroenteritis virus.
Keywords: Antiviral; Covid-19; SARS-CoV-2; autophagy; coronavirus; intensive care; polygenic score; polymorphism; risk; screening test; susceptibility; virophagy.
【저자키워드】 COVID-19, SARS-CoV-2, coronavirus, intensive care, Antiviral, susceptibility, polymorphism, risk, autophagy, virophagy., polygenic score, screening test, 【초록키워드】 coronavirus, Critical care, intensive care, Antiviral, hospital, Sequencing, Genome, Genetic, polymorphism, COVID-19 severity, severe acute respiratory syndrome Coronavirus, diarrhea, virus, autophagy, Endoplasmic reticulum, Papain-like protease, Protein, intensive care units, COVID-19 outbreak, Patient, Control, non-structural protein, membrane, genomes, respiratory, TGEV, resource, Intensive, Critical, screening test, Beclin 1, severe disease, COVID-19 patient, gastroenteritis, Middle East, referred to, light chain, mouse hepatitis, epidemic diarrhea, mouse hepatitis virus, acute respiratory syndrome, acute respiratory syndrome coronavirus, acute respiratory syndrome coronavirus 2, growth, bronchitis, effort, Papain, Infectious Bronchitis Virus, PEDV, Atg5, multifactorial, transmissible gastroenteritis virus, EGR1, Host, BECN1, PLP2, joint, highest, include, the patient, treated, less, determine, cause, embryonic, concerning, processed, Abbreviation, 【제목키워드】 Prognosis, Care, COVID-19 patient, multifactorial,