Abstract
The novel 2019 coronavirus disease (COVID-19), resulting from severe acute respiratory syndrome coronarvirus-2 (SARS-CoV-2) infection, typically leads to respiratory failure in severe cases; however, cardiovascular injury is reported to contribute to a substantial proportion of COVID-19 deaths. Preexisting cardiovascular disease (CVD) is among the most common risk factors for hospitalization and death in COVID-19 patients, and the pathogenic mechanisms of COVID-19 disease progression itself may promote the development of cardiovascular injury, increasing risk of in-hospital death. Sex differences in COVID-19 are becoming more apparent as mounting data indicate that males seem to be disproportionately at risk of severe COVID-19 outcome due to preexisting CVD and COVID-19-related cardiovascular injury. In this review, we will provide a basic science perspective on current clinical observations in this rapidly evolving field and discuss the interplay sex differences, preexisting CVD and COVID-19-related cardiac injury.
Keywords: ACE2; Arrhythmia; COVID-19; Cardiovascular; Sex differences; Thrombosis.
【저자키워드】 COVID-19, ACE2, thrombosis, arrhythmia, cardiovascular, sex differences, 【초록키워드】 coronavirus disease, SARS-CoV-2, coronavirus, Respiratory failure, thrombosis, severe COVID-19, Hospitalization, Infection, Sex, risk, cardiovascular disease, progression, outcome, risk factor, arrhythmia, COVID-19 disease, cardiovascular, cardiac injury, Severe acute respiratory syndrome, Disease progression, male, 2019 coronavirus disease, severe cases, respiratory, pathogenic mechanism, patients, COVID-19 patients, Basic science, Injury, deaths, leads, In-hospital death, CVD, acute respiratory syndrome, Perspective, pathogenic mechanisms, resulting, proportion, reported, contribute, promote, clinical observation, death in COVID-19, 【제목키워드】 Injury,