Abstract
COVID-19 pathology involves dysregulation of diverse molecular, cellular, and physiological processes. To expedite integrated and collaborative COVID-19 research, we completed multi-omics analysis of hospitalized COVID-19 patients, including matched analysis of the whole-blood transcriptome, plasma proteomics with two complementary platforms, cytokine profiling, plasma and red blood cell metabolomics, deep immune cell phenotyping by mass cytometry, and clinical data annotation. We refer to this multidimensional dataset as the COVIDome. We then created the COVIDome Explorer, an online researcher portal where the data can be analyzed and visualized in real time. We illustrate herein the use of the COVIDome dataset through a multi-omics analysis of biosignatures associated with C-reactive protein (CRP), an established marker of poor prognosis in COVID-19, revealing associations between CRP levels and damage-associated molecular patterns, depletion of protective serpins, and mitochondrial metabolism dysregulation. We expect that the COVIDome Explorer will rapidly accelerate data sharing, hypothesis testing, and discoveries worldwide.
Keywords: COVID-19; CRP; SARS; data portal; immune system; infection; inflammation; metabolism; multi-omics; serpins.
【저자키워드】 COVID-19, Inflammation, SARS, Infection, CRP, immune system, metabolism, Multi-omics, data portal, serpins., 【초록키워드】 Transcriptome, pathology, metabolomics, C-reactive protein, cytokine, immune system, metabolism, immune, plasma, dataset, molecular, plasma proteomics, Blood, Protective, red blood cell, association, marker, cellular, Hypothesis, Analysis, Immune cell, real time, Cytometry, complementary, serpins, physiological, mitochondrial, dysregulation, blood cell, portal, Damage-associated molecular patterns, hospitalized COVID-19 patients, Clinical data, damage, CRP levels, poor prognosis, Depletion, Hypothesis testing, CRP level, COVID-19 research, researcher, Cell, mitochondrial metabolism, analyzed, accelerate, multidimensional, 【제목키워드】 researcher,