Abstract
Objective: The aim of the study was to assess the role of midregional proadrenomedullin (MR-proADM) in patients with COVID-19.
Methods: We included 110 patients hospitalized for COVID-19. Biochemical biomarkers, including MR-proADM, were measured at admission. The association of plasma MR-proADM levels with COVID-19 severity, defined as a requirement for mechanical ventilation or in-hospital mortality, was evaluated.
Results: Patients showed increased levels of MR-proADM. In addition, MR-proADM was higher in patients who died during hospitalization than in patients who survived (median, 2.59 nmol/L; interquartile range, 2.3-2.95 vs median, 0.82 nmol/L; interquartile range, 0.57-1.03; P <.0001). Receiver operating characteristic curve analysis showed good accuracy of MR-proADM for predicting mortality. A MR-proADM value of 1.73 nmol/L was established as the best cutoff value, with 90% sensitivity and 95% specificity (P <.0001).
Conclusion: We found that MR-proADM could represent a prognostic biomarker of COVID-19.
Keywords: COVID-19; MR-proADM; biomarker; inflammation; respiratory disease.
【저자키워드】 COVID-19, Inflammation, Biomarker, Respiratory disease, MR-proADM, 【초록키워드】 Biomarker, Biomarkers, Mortality, mechanical ventilation, Hospitalization, severity, COVID-19 severity, sensitivity, specificity, Accuracy, Respiratory disease, Patient, plasma, respiratory, Admission, in-hospital mortality, prognostic biomarker, association, MR-proADM, Analysis, best, receiver operating characteristic, interquartile range, cutoff value, defined, died, addition, evaluated, median, were measured, patients hospitalized, patients who survived, patients with COVID-19, with COVID-19, 【제목키워드】 clinical, with COVID-19,