Abstract
BACKGROUND During the global Coronavirus Disease-2019 (COVID-19) pandemic, the Centers for Disease Control and Prevention (CDC) and the World Health Organization (WHO) have identified and monitored variants of concerns (VOCs) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). P.1 (Gamma) variant was initially identified in northern Brazil but has now spread worldwide. This is a report of a 48-year-old female resident of southern Florida with confirmed reinfection with P.1 variant 9 months following the initial infection. This patient was not immunocompromised and was not vaccinated. CASE REPORT A 48-year-old woman residing in southern Florida presented with symptoms of COVID-19 and tested positive for SARS-CoV-2 with oral swab polymerase chain reaction (PCR) in September 2020. Her symptoms resolved spontaneously after 5 days. Nine months later, the patient again presented with respiratory, digestive, and constitutional symptoms. The nasopharyngeal swab SARS-CoV-2 PCR was positive. At that time, she had not received any vaccinations against SARS-CoV-2. Whole-genome sequencing (WGS) of viral RNA from the patient’s second infection confirmed that the viral strain was P.1 variant containing the E484K spike protein substitution. CONCLUSIONS This report has identified a confirmed case of reinfection with P.1 variant of SARS-CoV-2 outside Brazil. This case supports recent epidemiological findings that indicate this VOC may have increased infectivity and virulence, and highlights the importance of SARS-CoV-2 vaccination for everyone.
【초록키워드】 COVID-19, Brazil, whole-genome sequencing, SARS-CoV-2, coronavirus, vaccination, pandemic, VoC, Sequencing, variant, Infection, variants of concern, prevention, Symptom, severe acute respiratory syndrome Coronavirus, Symptoms, variants, Spike protein, coronavirus disease-2019, Spread, Nasopharyngeal swab, polymerase chain reaction, Reinfection, Viral, PCR, CDC, P.1, disease control, female, VOCs, Patient, Control, Immunocompromised, Gamma, E484K, WHO, P.1 variant, Viral RNA, respiratory, WGS, virulence, SARS-CoV-2 vaccination, SARS-CoV-2 PCR, Health Organization, Chain Reaction, viral strain, Support, World Health Organization, acute respiratory syndrome, constitutional symptoms, acute respiratory syndrome coronavirus, acute respiratory syndrome coronavirus 2, center, symptoms of COVID-19, report, positive, oral swab, highlight, polymerase chain, initial, tested, the patient, digestive, resolved, epidemiological finding, 【제목키워드】 SARS-CoV-2, resident, P.1, Gamma, Confirmed,