Abstract
Formyl peptide receptor 1 (FPR1) is a pattern-recognition receptor that detects bacterial as well as endogenous danger-associated molecular patterns to trigger innate immune responses by myeloid cells. A single nucleotide polymorphism, rs867228 (allelic frequency 19-20%), in the gene coding for FPR1 accelerates the manifestation of multiple carcinomas, likely due to reduced anticancer immunosurveillance secondary to a defect in antigen presentation by dendritic cells. Another polymorphism in FPR1 , rs5030880 (allelic frequency 12-13%), has been involved in the resistance to plague, correlating with the fact that FPR1 is the receptor for Yersinia pestis . Driven by the reported preclinical effects of FPR1 on lung inflammation and fibrosis, we investigated whether rs867228 or rs5030880 would affect the severity of coronavirus disease-19 (COVID-19). Data obtained on patients from two different hospitals in Paris refute the hypothesis that rs867228 or rs5030880 would affect the severity of COVID-19.
Keywords: Immunogenetics; pathogen-associated molecular patterns; sars-CoV-2.
【저자키워드】 SARS-CoV-2., Immunogenetics, pathogen-associated molecular patterns, 【초록키워드】 COVID-19, coronavirus disease, coronavirus, innate immune response, severity, hospital, myeloid cells, polymorphism, peptide, fibrosis, dendritic cells, Coronavirus disease-19, pathogen, Single nucleotide polymorphism, severity of COVID-19, immune responses, Immunogenetics, Patient, pathogen-associated molecular patterns, receptor, Antigen presentation, single nucleotide, Bacterial, nucleotide, Hypothesis, Lung inflammation, Frequency, Trigger, manifestation, secondary to, Yersinia pestis, plague, Paris, coding, defect, anticancer, innate immune responses, FPR1, Effect, Affect, Yersinia, formyl, detect, involved, reported, investigated, reduced, allelic, accelerate, danger-associated molecular pattern, pathogen-associated molecular, 【제목키워드】 COVID-19, Cancer, polymorphism,