Abstract
Millions of people around the world are involved with COVID-19 due to infection with SARS-CoV-2. Virological features of SARS-CoV-2, including its genomic sequence, have been identified but the mechanisms governing COVID-19 immunopathogenesis have remained uncertain. miR-223 is a hematopoietic cell-derived miRNA that is implicated in regulating monocyte-macrophage differentiation, neutrophil recruitment, and pro-inflammatory responses. The miR-223 controls inflammation by targeting a variety of factors, including TRAF6, IKKα, HSP-70, FOXO1, TLR4, PI3K/AKT, PARP-1, HDAC2, ITGB3, CXCL2, CCL3, IL-6, IFN-I, STMN1, IL-1β, IL-18, Caspase-1, NF-κB, and NLRP3. The key role of miR-223 in regulating the inflammatory process and its antioxidant and antiviral role can suggest this miRNA as a potential regulatory factor in the process of COVID-19 immunopathogenesis.
Keywords: Acute lung injury; Acute respiratory distress syndrome; COVID-19; NLRP3 inflammasome; SARS-CoV-2; miR-223.
【저자키워드】 COVID-19, SARS-CoV-2, acute respiratory distress syndrome, NLRP3 inflammasome, acute lung injury, miR-223., 【초록키워드】 Inflammation, Respiratory distress syndrome, acute respiratory distress syndrome, IL-6, TLR4, neutrophil, miRNA, lung, Lung injury, antioxidant, NLRP3 inflammasome, acute lung injury, Regulatory, Immunopathogenesis, Control, Factors, IFN-I, PARP, caspase-1, mechanism, caspase, NF-κB, CCL3, NLRP3, IL-1β, distress, respiratory distress, pro-inflammatory responses, PI3K, CXCL2, neutrophil recruitment, inflammatory process, Traf6, IKKα, IL-18, FOXO1, genomic sequence, miR-223, HDAC2, ITGB3, antiviral role, feature, STMN1, involved, remained, monocyte-macrophage, variety, implicated, infection with SARS-CoV-2, with COVID-19, 【제목키워드】 Inflammation, Immunopathogenesis, inflammatory disease,