Long-term follow-up of 2000 patients with herpes zoster (HZ) in the department of viral neuroinfections as well as special HZ studies provided evidence for comprehensive evaluation of HZ pathogenesis. In addition to peripheral nervous system involvement, HZ is shown to cause systemic disorders typical for neuroviral infections. The principles of adequate pathogenetic therapy are validated. It is believed that relevant pathogenetic studies contribute to the development of general pathology.
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