Abstract
We used transcriptomic (RNA-seq) analyses to determine whether patients suffering from all types and subtypes of mucopolysaccharidosis (MPS), a severe inherited metabolic disease, may be more susceptible to coronavirus disease 2019 (COVID-19). The expression levels of genes encoding proteins potentially involved in SARS-CoV-2 development were estimated in MPS cell lines. Four genes (GTF2F2, RAB18, TMEM97, PDE4DIP) coding for proteins potentially facilitating virus development were down-regulated, while two genes (FBN1, MFGE8), the products of which potentially interfere with virus propagation, were up-regulated in most MPS types. Although narrowing of respiratory tract and occurrence of thick mucus, characteristic of MPS, are risk factors for COVID-19, transcriptomic analyses suggest that MPS cells might be less, rather than more, susceptible to SARS-CoV-2 infection.
Keywords: COVID-19; mucopolysaccharidosis; transcriptomic analyses.
【저자키워드】 COVID-19, mucopolysaccharidosis, transcriptomic analyses., 【초록키워드】 coronavirus disease, SARS-CoV-2, Coronavirus disease 2019, Risk factors, SARS-COV-2 infection, risk factor, virus, Protein, RNA-Seq, metabolic disease, Patient, respiratory tract, respiratory, characteristic, mucopolysaccharidosis, Analysis, cell lines, MPS, Subtypes, expression level, coding, expression levels, Transcriptomic analyses, subtype, transcriptomic, susceptible, Cell, FBN1, GTF2F2, inherited metabolic disease, MFGE8, PDE4DIP, RAB18, TMEM97, virus propagation, Occurrence, involved, less, determine, interfere, analyses, up-regulated, genes encoding, down-regulated, 【제목키워드】 Patient, transcriptomic analysis, susceptible, less,