Abstract
The angiotensin-converting enzyme 2 (ACE2) receptor has been proved for SARS-CoV-2 cell entry after auxiliary cellular protease priming by transmembrane protease serine 2 (TMPRSS2), but the co-effect of this molecular mechanism was unknown. Here, single-cell sequencing was performed with human conjunctiva and the results have shown that ACE2 and TMPRSS2 were highly co-expressed in the goblet cells with genes involved in immunity process. This identification of conjunctival cell types which are permissive to virus entry would help to understand the process by which SARS-CoV-2 infection was established. These finding might be suggestive for COVID-19 control and protection.
Keywords: ACE2; Conjunctival goblet cell; SARS‐CoV‐2; TMPRSS2.
【저자키워드】 ACE2, SARS‐CoV‐2, Conjunctival goblet cell, TMPRSS2, 【초록키워드】 COVID-19, Immunity, SARS-COV-2 infection, Sequencing, protease, molecular mechanism, angiotensin-converting enzyme 2, virus entry, receptor, transmembrane protease serine 2, single-cell, Angiotensin-converting enzyme, angiotensin, cell types, cell type, goblet cells, Serine, goblet, help, transmembrane, priming, conjunctival, cellular protease, serine 2, Goblet cell, shown, involved, was performed, co-expressed, auxiliary, SARS-CoV-2 cell, 【제목키워드】 Factor, conjunctival, expression of SARS-CoV-2,