Abstract
Follicular dendritic cell (FDC) proliferation in angioimmunoblastic T-cell lymphoma (AITL) is still not well defined, challenging the accurate differential diagnosis between the AITL with expanded follicular dendritic cell meshwork and the combined AITL and follicular dendritic cell sarcoma (FDCS). Herein, we reported the case of a 58-year-old male with coexisting SARS-CoV-2 infection and AITL with an exuberant CD30-positive FDC proliferation, in which genetic analysis identified mutations of genes commonly involved in AITL but not in FDC sarcoma (i.e., RHOA, TET2, DNMT3A, and IDH2), thus supporting the reactive nature of the CD30-positive FDC expansion.
Keywords: AITL; CD30 expression; SARS-CoV-2 infection; follicular dendritic cell proliferation.
【저자키워드】 SARS-COV-2 infection, AITL, CD30 expression, follicular dendritic cell proliferation., 【초록키워드】 SARS-CoV-2, Mutation, SARS-COV-2 infection, lymphoma, male, T-cell, Sarcoma, differential diagnosis, dendritic cell, proliferation, angioimmunoblastic T-cell lymphoma, genetic analysis, DNMT3A, RHOA, reactive, CD30, IDH2, T-Cell Lymphoma, TET2, defined, involved, reported, follicular, 【제목키워드】 SARS-CoV-2, role, Exclude, Exuberant,