Abstract in English, Spanish
Objective: The aim of this study was to analyze in a prospective cohort of hospitalized COVID-19 patients the relationship between biomarkers levels and their variation within the first 4 days since admission, and prognosis.
Methods: Prospective cohort study. Individuals with confirmed diagnosis of covid-19 admitted in our hospital were included. Blood samples were obtained systematically on days 1 and 4 of hospitalization. Levels of RCP, LDH, Ferritin and D-dimer, together with platelets, lymphocytes and neutrophils counts were measured. A combined outcome that included ICU admission and death was considered the primary outcome. Logistic regression analysis was performed.
Results: We included 335 patients with confirmed COVID-19. During their hospitalization, 23 (6.8%) needed ICU admission, and 10 (2.9%) died. In the multivariate analysis, a value of RCP greater than 10 mg/dl (OR 8.69, CI95% 1.45-52), an increase in RCP greater than 20% (OR 26.08, CI 95% 3.21-211.3), an increase in LDH greater than 20% (OR 6.29, CI 95% 1.84-21.44), a count of lymphocytes lower than 1500/mm3 (OR 2.74, CI 95% 1.04-7.23), a D-dimer value greater than 550 ng/ml (OR 9.8, CI 95% 1.78-53.9) and a neutrophil/lymphocyte index greater than 3(OR 4.5, CI 95% 1.43-14.19) were all associated with the primary outcome.
Conclusions: Our study shows that the utilization of static and dynamic biomarkers may represent an important tool to assess prognosis of COVID-19 patients.
Objetivo: El objetivo de este estudio es analizar en una cohorte prospectiva de pacientes internados por COVID-19, el valor pronóstico de los niveles de biomarcadores y su variación en los primeros cuatro días de internación.
Material y métodos: Estudio de cohorte prospectivo. Se incluyeron individuos con diagnóstico confirmado de COVID-19 ingresados en nuestro hospital. Se obtuvieron muestras de sangre de forma sistemática los días 1 y 4 de internación. Se midieron los niveles de PCR, LDH, ferritina y dímero-D, junto con recuento de plaquetas, linfocitos y neutrófilos. Una variable de desenlace combinada que incluía la admisión a la UCI y la muerte se consideró como resultado primario. Se realizó un análisis de regresión logística.
Resultados: Se incluyeron 335 pacientes con COVID-19 confirmado. Durante su internación, 23 (6,8%) necesitaron ingreso en UCI y 10 (2,9%) fallecieron. En el análisis multivariado, un valor de PCR superior a 10 mg/dl (OR 8,69, IC 95% 1,45-52), un aumento de PCR superior al 20% (OR 26,08, IC 95% 3,21-211,3), un aumento de LDH superior al 20% (OR 6,29, IC 95% 1,84-21,44), un recuento de linfocitos inferior a 1500/mm3 (OR 2,74, IC 95% 1,04-7,23), un valor de dímero-D superior a 550 ng/ml (OR 9,8, IC 95% 1,78-53,9) y un índice de neutrófilos/linfocitos superior a 3 (OR 4,5, IC 95% 1,43-14,19) se asociaron con el resultado primario.
Conclusión: Nuestro estudio muestra que la utilización de biomarcadores estáticos y dinámicos puede representar una herramienta importante para evaluar el pronóstico de los pacientes con COVID-19.
Keywords: COVID-19; biomarkers; inflammation.
【저자키워드】 COVID-19, Inflammation, Biomarkers, 【초록키워드】 Neutrophils, Inflammation, Biomarker, Biomarkers, Lymphocytes, Prognosis, Hospitalization, hospital, Variation, neutrophil, Diagnosis, LDH, D-dimer, ferritin, Platelets, outcome, prospective cohort study, cohort study, lymphocyte, PCR, Prospective, Patient, ICU admission, death, prospective cohort, utilization, Admission, COVID-19 patients, Multivariate analysis, hospitalized COVID-19 patient, Ferritina, Analysis, regression analysis, Logistic regression analysis, Primary outcome, hospitalized COVID-19 patients, Blood samples, individual, blood sample, dimer, material, count, D-dimer value, Spanish, English, greater, died, was performed, increase in, Level, were measured, prospectivo, 【제목키워드】 Biomarker,