Abstract
Background: Cardiovascular disease (CVD) was in common in coronavirus disease 2019 (COVID-19) patients and associated with unfavorable outcomes. We aimed to compare the clinical observations and outcomes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected patients with or without CVD.
Methods: Patients with laboratory-confirmed SARS-CoV-2 infection were clinically evaluated at Wuhan Seventh People’s Hospital, Wuhan, China, from 23 January to 14 March 2020. Demographic data, laboratory findings, comorbidities, treatments and outcomes were collected and analyzed in COVID-19 patients with and without CVD.
Results: Among 596 patients with COVID-19, 215 (36.1%) of them with CVD. Compared with patients without CVD, these patients were significantly older (66 vs. 52 years) and had higher proportion of men (52.5% vs. 43.8%). Complications in the course of disease were more common in patients with CVD, included acute respiratory distress syndrome (22.8% vs. 8.1%), malignant arrhythmias (3.7% vs. 1.0%) including ventricular tachycardia/ventricular fibrillation, acute coagulopathy(7.9% vs. 1.8%) and acute kidney injury (11.6% vs. 3.4%). The rate of glucocorticoid therapy (36.7% vs. 25.5%), Vitamin C (23.3% vs. 11.8%), mechanical ventilation (21.9% vs. 7.6%), intensive care unit admission (12.6% vs. 3.7%) and mortality (16.7% vs. 4.7%) were higher in patients with CVD (both P < 0.05). The multivariable Cox regression models showed that older age (≥65 years old) (HR 3.165, 95% CI 1.722-5.817) and patients with CVD (HR 2.166, 95% CI 1.189-3.948) were independent risk factors for death.
Conclusions: CVD are independent risk factors for COVID-19 patients. COVID-19 patients with CVD were more severe and had higher mortality rate, early intervention and vigilance should be taken.
【초록키워드】 COVID-19, Treatment, coronavirus disease, Coronavirus disease 2019, coronavirus, therapy, Mortality, intensive care, acute respiratory distress syndrome, mechanical ventilation, SARS-COV-2 infection, Vitamin C, Comorbidities, cardiovascular disease, Intervention, Acute kidney injury, outcome, severe acute respiratory syndrome Coronavirus, glucocorticoid, arrhythmia, Laboratory, laboratory findings, cardiovascular, outcomes, Wuhan, Patient, Older age, death, Complication, Vitamin, mortality rate, respiratory, demographic, disease, Admission, COVID-19 patients, acute respiratory distress, clinical observations, intensive care unit admission, COVID-19 patient, respiratory distress, ventricular tachycardia, ventricular fibrillation, CVD, acute respiratory syndrome, Older, 95% CI, acute respiratory syndrome coronavirus, acute respiratory syndrome coronavirus 2, independent risk factors, demographic data, syndrome, laboratory-confirmed SARS-CoV-2 infection, independent risk factor, Vigilance, multivariable Cox regression, men, acute coagulopathy, Wuhan, China, Course, analyzed, collected, significantly, proportion, clinical observation, clinically evaluated, patients with COVID-19, ventricular, 【제목키워드】 Infection, disease risk, death in COVID-19,