Abstract
Patients with coronavirus disease 2019 (COVID-19) can present with distinct neurological manifestations. This study shows that inflammatory neurological diseases were associated with increased levels of interleukin (IL)-2, IL-4, IL-6, IL-10, IL-12, chemokine (C-X-C motif) ligand 8 (CXCL8), and CXCL10 in the cerebrospinal fluid. Conversely, encephalopathy was associated with high serum levels of IL-6, CXCL8, and active tumor growth factor β1. Inflammatory syndromes of the central nervous system in COVID-19 can appear early, as a parainfectious process without significant systemic involvement, or without direct evidence of severe acute respiratory syndrome coronavirus 2 neuroinvasion. At the same time, encephalopathy is mainly influenced by peripheral events, including inflammatory cytokines. ANN NEUROL 2021;89:1041-1045.
【초록키워드】 COVID-19, coronavirus disease, Tumor, Coronavirus disease 2019, coronavirus, Cytokines, IL-6, CXCL10, chemokine, interleukin, neurological manifestations, Encephalopathy, Inflammatory cytokines, Central nervous system, cerebrospinal fluid, IL-10, respiratory, CXCL8, IL-4, Evidence, Ligand, Inflammatory, ANN, evidence of, tumor growth, Neurological disease, acute respiratory syndrome, Serum level, syndrome, IL-12, Neurological diseases, motif, events, 【제목키워드】 pattern,