Comparative studies of measles vaccines in a controlled trial in the USSR

Published on
Journal: Bulletin of the World Health Organization
[저자] V M Bolotovskij, L A Nefedova, B G Gelikman, A T Zargaryants, L P Zetilova, K T Nastasina
[Category] Fulltext, 홍역,
PMC URL    Pubmed URL    
[Article Type] Comparative Study
[Source] pubmed

This paper describes the results of a study of measles vaccines carried out in the USSR on 866 children aged 12-54 months as part of a WHO-sponsored collaborative programme of investigation on live and killed measles vaccines. The live vaccines studied were Beckenham 20, Enders Edmonston B, Milovanović, Schwarz and Smorodincev. Of these, Beckenham 20 caused the most reaction (as assessed by pyrexia and rash) and Milovanović the least. Antibody responses were highest for Beckenham 20 and Schwarz vaccines and for Enders Edmonston vaccine plus gamma-globulin. A study was also made of the effect of one inoculation of Pfizer (killed) vaccine followed by one of Enders Edmonston B or Smorodincev live vaccine; very few reactions were observed in children vaccinated in this way and the antibody response was good.

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