Abstract
The aim of the study was to evaluate the vitamin D status in hospitalized COVID-19 patients and the correlation with C reactive protein (CRP), ferritin, fibrinogen, and peripheral blood leukocytes, as well as inflammatory derived indices. A prospective study was performed on 203 COVID-19 hospitalized patients, classified by disease severity. Blood was collected after admission, and inflammatory biomarkers and vitamin D status were assessed using routine laboratory procedures. No significant correlation was found between vitamin D serum levels and disease severity stratified by different age groups. However, the highest vitamin D levels were found in patients with mild disease: median 29.39 (IQR 12.12-44.02) ng/mL, while for moderate and severe forms the serum levels were significantly lower: median 15.10 (IQR 9.56-24.11) ng/mL for moderate, and 18.86 (IQR 12.50-27.88) ng/mL for severe; p = 0.009. Patients with no comorbidities showed a significantly higher level of vitamin D median 24.72 (IQR 16.05-31.52) ng/mL compared to subjects with at least one comorbidity: median 16.02 (IQR 9.81-25.22) ng/mL, p = 0.004. We did not find an association between vitamin D levels and inflammatory biomarkers except for significantly lower vitamin D levels in moderate and severe COVID-19 compared to mild disease forms.
Keywords: COVID-19; inflammation; vitamin D.
【저자키워드】 COVID-19, Inflammation, vitamin D., 【초록키워드】 severe COVID-19, Vitamin D, disease severity, Prospective Study, Comorbidities, Comorbidity, CRP, ferritin, hospitalized patients, Laboratory, Peripheral blood, Patient, Mild, fibrinogen, age, correlation, disease, Admission, moderate, Mild disease, association, leukocytes, inflammatory biomarkers, hospitalized COVID-19 patient, Vitamin D status, Inflammatory biomarker, Inflammatory, except for, C reactive protein, laboratory procedures, hospitalized COVID-19 patients, Serum level, subject, serum levels, vitamin D level, vitamin D levels, significantly lower, forms, peripheral blood leukocytes, highest, evaluate, significantly, form, was collected, was performed, median, significantly higher, groups, stratified, IQR, vitamin D serum, were assessed, 【제목키워드】 review, literature, experience,