Abstract
Background: Coagulopathy and inflammation are associated with coronavirus disease 2019 (COVID-19) severity. This study assessed D-dimer concentration and its correlation with inflammatory markers and COVID-19 severity.
Methods: This was a retrospective cross-sectional study involving 194 COVID-19 cases, with the severity of infection graded in accordance with the World Health Organization (WHO) guidelines. We measured D-dimer, C-reactive protein (CRP), and ferritin on admission and determined the cutoff values for D-dimer and CRP and evaluated the correlation between D-dimer and CRP and ferritin.
Results: Median D-dimer, CRP, and ferritin concentrations were 2240 µg/L, 73.2 mg/L, and 1173.8 µg/mL, respectively. The highest median D-dimer value was seen in mild and moderate acute respiratory distress syndrome (ARDS). The highest ferritin concentration was seen in severe ARDS. There was a significant correlation between D-dimer value and CRP (r = 0.327), but no significant correlation between D-dimer and ferritin (r = 0.101). The area under the receiver operating characteristic curve (AUC) for the combination of CRP ≥72.65 mg/L and D-dimer ≥1250 µg/L as a marker of COVID-19 severity was 0.722 (95% confidence interval (CI): 0.615-0.781).
Conclusion: The combination of CRP ≥72.65 mg/L and D-dimer ≥1250 µg/L can be used as marker of COVID-19 severity, with moderate accuracy.
Keywords: C-reactive protein; Coronavirus disease 2019; D-dimer; acute respiratory distress syndrome; correlation; ferritin; inflammation; severity.
【저자키워드】 Inflammation, Coronavirus disease 2019, acute respiratory distress syndrome, severity, C-reactive protein, D-dimer, ferritin, correlation, 【초록키워드】 COVID-19, coronavirus disease, Respiratory distress syndrome, Coronavirus disease 2019, ARDS, coronavirus, acute respiratory distress syndrome, severity, inflammatory markers, COVID-19 severity, C-reactive protein, CRP, D-dimer, ferritin, Coagulopathy, cross-sectional study, Accuracy, Mild, WHO, Inflammatory marker, characteristic, disease, Admission, moderate, acute respiratory distress, marker, Combination, Concentration, COVID-19 cases, AUC, on admission, respiratory distress, Health Organization, receiver operating characteristic, World Health Organization, 95% confidence interval, severe ARDS, syndrome, dimer, receiver, Severity of infection, cutoff value, D-dimer value, Retrospective cross-sectional study, highest, evaluated, median, can be used, 【제목키워드】 hospital, National,