Abstract
The angiotensin-converting enzyme 2 (ACE2) is a type I integral membrane that was discovered two decades ago. The ACE2 exists as a transmembrane protein and as a soluble catalytic ectodomain of ACE2, also known as the soluble ACE2 that can be found in plasma and other body fluids. ACE2 regulates the local actions of the renin-angiotensin system in cardiovascular tissues, and the ACE2/Angiotensin 1-7 axis exerts protective actions in cardiovascular disease. Increasing soluble ACE2 has been associated with heart failure, cardiovascular disease, and cardiac remodelling. This is a review of the molecular structure and biochemical functions of the ACE2, as well we provided an updated on the evidence, clinical applications, and emerging potential therapies with the ACE2 in heart failure, cardiovascular disease, lung injury, and COVID-19 infection.
Keywords: ACE2; Angiotensin 1-7; COVID-19; Chelation therapy; SARS-CoV-2; cardiac remodelling; heart failure; lung injury; soluble ACE2; soluble catalytic ectodomain of ACE2.
【저자키워드】 COVID-19, SARS-CoV-2, ACE2, Lung injury, heart failure, Angiotensin 1-7, Chelation therapy, cardiac remodelling, soluble ACE2, soluble catalytic ectodomain of ACE2., 【초록키워드】 lung, cardiovascular disease, Local, Lung injury, angiotensin-converting enzyme 2, renin-angiotensin system, heart failure, COVID-19 infection, membrane, plasma, molecular, function, Protective, Angiotensin-converting enzyme, Angiotensin 1-7, soluble ACE2, Evidence, angiotensin, regulate, body fluids, Renin, biochemical, tissues, type I, ectodomain, transmembrane protein, chelation, potential therapy, provided, Increasing, catalytic, 【제목키워드】 COVID19, Biomarker, ectodomain, catalytic,