Abstract
Background: Triglyceride-glucose (TyG) index is a simple and reliable surrogate marker for insulin resistance. Epidemiology studies have shown that insulin resistance is a risk factor for various infectious diseases. We evaluated the prognostic value of TyG index measured before the COVID-19 infection in COVID-19 infected patients.
Methods: From a nationwide COVID-19 cohort dataset in Korea, we included COVID-19 patients diagnosed between Jan and Jun 2020. Based on the nationwide health screening data between 2015 and 2018, TyG index was calculated as ln [triglyceride (mg/dL) × fasting glucose level (mg/dL)/2]. Primary outcome is development of severe complications of COVID-19 defined as composite of mechanical ventilation, intensive care unit care, high-flow oxygen therapy, and mortality within two months after the diagnosis of COVID-19.
Results: This study included 3887 patients with COVID-19 confirmed by reverse transcription polymerase chain reaction. Mean ± standard deviation of TyG index was 8.54 ± 0.61. Severe complications of COVID-19 were noted in 289 (7.44%) patients. In the multivariate logistic regression, TyG index was positively associated with severe complications of COVID-19 (adjusted odds ratio: 1.42, 95% confidence interval [1.12-1.79]).
Conclusions: In COVID-19 infected patients, high TyG index was associated with increased risk for severe complications. TyG index might be useful predictor for the severity of COVID-19 infection.
Keywords: COVID-19; Glucose; Insulin resistance; Triglyceride-glucose index.
【저자키워드】 COVID-19, insulin resistance, Glucose, Triglyceride-glucose index., 【초록키워드】 Infectious diseases, Diseases, Mortality, intensive care, mechanical ventilation, Infection, oxygen, outcome, risk factor, reverse transcription polymerase chain reaction, polymerase chain reaction, Health, COVID-19 infection, severity of COVID-19, insulin resistance, Triglyceride, Oxygen therapy, dataset, reverse transcription, insulin, Care, patients, Glucose, COVID-19 patients, marker, Composite, COVID-19 patient, Chain Reaction, health screening, Standard deviation, Prognostic value, adjusted odds ratio, Primary outcome, infected patients, 95% confidence interval, increased risk, multivariate logistic regression, severe complications, complications of COVID-19, COVID-19 cohort, COVID-19 infected patients, high-flow oxygen therapy, Mean ± standard deviation, fasting glucose, polymerase chain, defined, shown, diagnosed, evaluated, calculated, adjusted, severe complication, diagnosis of COVID-19, patients with COVID-19, 【제목키워드】 Prognosis,