Abstract
To conduct a systematic review and meta-analysis to characterize inflammatory markers in comparisons of multisystem inflammatory syndrome in children (MIS-C) versus severe/non-severe COVID-19, severe MIS-C versus non-severe MIS-C, and among age groups of MIS-C. Nine databases were searched for studies on inflammatory markers of MIS-C. After quality checks, data were pooled using a fixed or random effects model. Inflammatory markers included white blood cell count (WBC) or leukocytes, absolute lymphocyte count (ALC), absolute neutrophil count (ANC), platelet count (PLT), C-reactive protein (CRP), procalcitonin (PCT), ferritin, D-dimer, lactate dehydrogenase (LDH), fibrinogen, and erythrocyte sedimentation rate (ESR) for comparisons by severity and age. Twenty-one studies with 1735 participants yielded 787 MIS-C patients. Compared to non-severe COVID-19 patients, MIS-C patients had lower ALC and higher ANC, CRP, and D-dimer levels. Compared to severe COVID-19 patients, MIS-C patients had lower LDH and PLT counts and higher ESR levels. Severe MIS-C patients had higher levels of WBC, ANC, CRP, D-dimer, and ferritin than non-severe MIS-C patients. For MIS-C, younger children (0-5 years) had lower CRP and ferritin levels than middle-aged/older children/adolescents. Measurement of inflammatory markers might assist clinicians in accurate evaluation and diagnosis of MIS-C and the associated disorders.
Keywords: COVID-19; MIS-C/PMIS/PIMS-TS; SARS-CoV-2; inflammatory markers; meta-analysis; pediatrics.
【저자키워드】 COVID-19, Meta-analysis, SARS-CoV-2, inflammatory markers, pediatrics, MIS-C/PMIS/PIMS-TS, 【초록키워드】 Meta-analysis, children, severity, neutrophil, inflammatory markers, Diagnosis, LDH, systematic review, C-reactive protein, CRP, D-dimer, ferritin, procalcitonin, lactate dehydrogenase, database, MIS-C, lymphocyte, pediatrics, White blood cell, comparison, Patient, Platelet, fibrinogen, age, ESR, Inflammatory marker, WBC, group, patients, COVID-19 patients, PIMS, Platelet count, leukocytes, marker, Absolute lymphocyte count, Lactate, Inflammatory, erythrocyte sedimentation, blood cell, erythrocyte sedimentation rate, sedimentation rate, D-dimer levels, disorders, clinician, white blood cell count, Comparisons, syndrome, severe COVID-19 patients, participant, absolute neutrophil count, random effect, measurement, PCT, quality checks, searched, fixed, assist, ALC, ANC, ferritin level, 【제목키워드】 children, Inflammatory marker, Inflammatory, syndrome,