Abstract
Aim: To evaluate the prediction capacity of urinary biomarkers for death in critically ill patients with COVID-19. Methods: This is a prospective study with critically ill patients due to COVID-19 infection. The urinary biomarkers NGAL, KIM-1, MCP-1 and nephrin were quantified on ICU admission. Results: There was 40% of death. Urinary nephrin and MCP-1 had no association with death. Tubular biomarkers (proteinuria, NGAL and KIM-1) were predictors of death and cut-off values of them for death were useful in stratify patients with worse prognosis. In a multivariate cox regression analysis, only NGAL remains associated with a two-mount survival chance. Conclusion: Kidney tubular biomarkers, mostly urinary NGAL, had useful capacity to predict death in critically ill COVID-19 patients.
Keywords: COVID-19; NGAL; death; kidney biomarkers.
【저자키워드】 COVID-19, death, NGAL, kidney biomarkers., 【초록키워드】 Biomarker, Biomarkers, Prospective Study, kidney, survival, Proteinuria, Critically ill, COVID-19 infection, Patient, ICU admission, MCP-1, predictor, predict, critically ill patients, COVID-19 patients, association, critically ill COVID-19 patients, regression analysis, Critically ill patient, Cox regression analysis, worse prognosis, multivariate, cut-off value, multivariate Cox regression analysis, tubular, urinary, nephrin, evaluate, had no, quantified, with COVID-19, 【제목키워드】 Biomarker, predictor, Critically ill patient, urinary, with COVID-19,