Abstract
We assessed the expression of CD169, a type I interferon-inducible receptor, on monocytes (monocyte CD169 [mCD169]) in 53 adult patients admitted to the hospital during the coronavirus disease 2019 (COVID-19) outbreak for a suspicion of severe acute respiratory syndrome coronavirus 2 infection. Monocyte CD169 was strongly overexpressed in 30 of 32 (93.7%) confirmed COVID-19 cases, compared with 3 of 21 (14.3%) patients in whom the diagnosis of COVID-19 was finally ruled out. Monocyte CD169 was associated with the plasma interferon-alpha level and thrombocytopenia. Monocyte CD169 testing may be helpful for the rapid triage of suspected COVID-19 patients during an outbreak.
Keywords: CD169; COVID-19; SARS-CoV-2; monocytes; viral infections.
【저자키워드】 COVID-19, Monocytes, SARS-CoV-2, viral infections, CD169, 【초록키워드】 coronavirus disease, Monocytes, interferon-alpha, Coronavirus disease 2019, coronavirus, hospital, Infection, severe acute respiratory syndrome Coronavirus, viral infections, monocyte, Viral, outbreak, Patient, plasma, thrombocytopenia, receptor, respiratory, expression, CD169, COVID-19 cases, COVID-19 patient, acute respiratory syndrome, type I, suspicion, overexpressed, diagnosis of COVID-19, 【제목키워드】 Coronavirus disease 2019, monocyte,