Abstract
The SARS-CoV-2 virus has spread to all corners of the world. Thrombosis is the cause of organ failure and subsequent death in COVID-19. The pathophysiology of thrombosis in COVID-19 needs to be further explored to shed light on its downside. For this reason, this meta-analysis of Von Willebrand Factor profile (VWF: Ag, VWF: activity, VWF: RCo), ADAMTS-13, and factor VIII levels in COVID-19 was performed. To obtain data on the status of the aforementioned hemostatic factors, a systematic literature review and meta-analysis were performed on COVID-19. After reviewing the evaluation of 348 papers, 28 papers included in the meta-analysis, which was performed using STATA. The analysis showed an increase in VWF: Ag levels in COVID-19 patients. VWF: Ac was higher in all COVID-19 patients, while it was lower in the COVID-19 ICU patients. The pooled mean of VWF: RCO in all patients with COVID-19 was 307.94%. In subgroup analysis, VWF: RCO was significantly higher in ICU patients than in all COVID-19 patients. The pooled mean of ADAMTS-13 activity was 62.47%, and 58.42% in ICU patients. The pooled mean of factor VIII level was 275.8%, which was significantly higher in ICU patients with COVID-19 than all patients with COVID-19. Levels of VWF: Ag, VWF: activity, VWF: ristocetin, and factor VIII are increased in patients with COVID-19. The elevated levels in ICU patients with COVID-19 suggest that these markers may have prognostic value in determining the severity of COVID-19. New therapeutic programs can be developed as a result.
Keywords: ADAMTS-13; COVID-19; Factor VIII level; Thrombosis; VWF:AC; VWF:Ag; VWF:Co.
【저자키워드】 COVID-19, thrombosis, ADAMTS-13, Factor VIII level, VWF:AC, VWF:Ag, VWF:Co., 【초록키워드】 Meta-analysis, thrombosis, SARS-CoV-2 virus, pathophysiology, severity of COVID-19, therapeutic, Factors, ICU Patients, COVID-19 patients, marker, factor VIII, Analysis, Organ failure, literature review, Prognostic value, Factor, status, subgroup analysis, Stata, ICU patient, ADAMTS, performed, spread to, subsequent, elevated, was performed, increase in, significantly higher, Level, New, death in COVID-19, patients with COVID-19, with COVID-19, 【제목키워드】 systematic review, marker,