Abstract
To date, proposed therapies and antiviral drugs have been failed to cure coronavirus disease 2019 (COVID-19) patients. However, at least two drug companies have applied for emergency use authorization with the United States Food and Drug Administration for their coronavirus vaccine candidates and several other vaccines are in various stages of development to determine safety and efficacy. Recently, some studies have shown the role of different human and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) microRNAs (miRNAs) in the pathophysiology of COVID-19. miRNAs are non-coding single-stranded RNAs, which are involved in several physiological and pathological conditions, such as cell proliferation, differentiation, and metabolism. They act as negative regulators of protein synthesis through binding to the 3′ untranslated region (3′ UTR) of the complementary target mRNA, leading to mRNA degradation or inhibition. The databases of Google Scholar, Scopus, PubMed, and Web of Science were searched for literature regarding the importance of miRNAs in the SARS-CoV-2 life cycle, pathogenesis, and genomic mutations. Furthermore, promising miRNAs as a biomarker or antiviral agent in COVID-19 therapy are reviewed.
Keywords: COVID-19; MicroRNA; SARS-CoV-2; patogenecity; virus.
【저자키워드】 COVID-19, SARS-CoV-2, microRNA, virus, patogenecity, 【초록키워드】 coronavirus disease, Coronavirus disease 2019, Efficacy, Vaccine, coronavirus, therapy, Biomarker, Pathogenesis, Antiviral, microRNA, mutations, antiviral drugs, miRNA, drug, severe acute respiratory syndrome Coronavirus, virus, database, Emergency use authorization, RNAs, metabolism, antiviral drug, databases, miRNAs, pathophysiology, coronavirus vaccine, COVID-19 therapy, United States, respiratory, differentiation, antiviral agent, UTR, genomic, patients, binding, food, protein synthesis, complementary, physiological, cell proliferation, life cycle, untranslated region, Google Scholar, genomic mutations, acute respiratory syndrome, Web of Science, acute respiratory syndrome coronavirus, acute respiratory syndrome coronavirus 2, SARS-CoV-2 life cycle, Stage, candidate, Drug administration, pathological conditions, mRNA degradation, United States Food and Drug Administration, target mRNA, single-stranded, shown, involved, the United State, applied, searched, determine, the SARS-CoV-2, 【제목키워드】 therapeutic,