Abstract
Introduction and objectives: Since the outbreak of the COVID-19 pandemic, increasing evidence suggests that infected patients present a high incidence of venous thromboembolic (VTE) events and elevated aminotransferases (AT).The objective of this work was to evaluate the incidence of aminotransferases disorders in patients infected with COVID-19 and to manage the VTE events associated with elevated AT.
Patients or materials and methods: We report a retrospective study of 46 patients admitted for COVID-19 infection. Venous duplex ultrasound of lower limbs was performed in all patients at Day 0 and Day 5. All patients had antithrombotic-prophylaxis upon admission using low molecular weight heparin with Enoxaparin. Demographics, comorbidities and laboratory parameters were collected and analyzed.
Results: Elevated AT were reported in 28 patients (61%). 10 had acute VTE events of which eight (17.4%) had aminotransferases disorders. They had been treated with curative Enoxaparin. After a follow-up of 15 and/or 30 days, six of them were controlled, and treated with direct oral anticoagulant (DOACs) after normalization of aminotransferases.
Conclusions: The incidence of aminotransferases disorders associated with acute VTE events in patients infected with COVID-19 is significant. The use of DOACs appear pertinent in these patients. Monitoring of the liver balance should therefore be considered at a distance from the acute episode in the perspective of DOACs relay.
Keywords: Aminotransferases disorders; COVID-19; Direct oral anticoagulant; Elevated AST and ALT; Liver disorders; Venous thromboembolism.
【저자키워드】 COVID-19, Venous Thromboembolism, Aminotransferases disorders, Direct oral anticoagulant, Elevated AST and ALT, Liver disorders, 【초록키워드】 COVID-19 pandemic, Comorbidities, Comorbidity, heparin, Venous Thromboembolism, Retrospective study, COVID-19 infection, outbreak, Patient, Thromboembolism, enoxaparin, Laboratory parameters, AST, monitoring, Follow-up, incidence, Admission, liver, patients, Liver disorders, Anticoagulant, Evidence, VTE, demographics, balance, low molecular weight, lower limb, lower limbs, low molecular weight heparin, infected patients, disorders, Perspective, distance, normalization, disorder, venous thromboembolic, Direct, DOACs, DOAC, laboratory parameter, Aminotransferase, event, analyzed, collected, evaluate, reported, Day, elevated, eight, was performed, treated, infected patient, curative, infected with COVID-19, 【제목키워드】 Patient, disorder, Aminotransferase, event, infected with COVID-19,