Abstract
There is limited data on the clinical presentation and predictors of mortality in the African-American (AA) patients hospitalized with coronavirus disease 2019 (COVID-19) despite the disproportionately higher burden and mortality. The aim of this study is to report on the clinical characteristics and the predictors of mortality in hospitalized AA patients with COVID-19 infection. In this retrospective cohort review, we included all AA patients with confirmed COVID-19 infection admitted to an inner-city teaching community hospital in New York city. Demographics, clinical presentation, baseline co-morbidities, and laboratory data were compared between survivors and non-survivors. The predictors of mortality were assessed using multivariate logistic regression analysis. Of the 408 (median age, 67 years) patients included, 276 (66.65%, median age 63 years) survived while 132 (33.35%, median age 71 years) died. The most common presenting symptoms were cough, myalgia, fever/chills, shortness of breath, and gastrointestinal symptoms (nausea, vomiting, diarrhea, and abdominal pain), with a prevalence of 62.50%, 43.87%, 53.68%, and 27.21%, respectively. Age (odds ratio [OR], 1.06; confidence interval [CI], 1.04-1.08; P < .001), body mass index (OR, 1.07; CI, 1.04-1.11; P < .001), elevated serum ferritin (OR, 1.99; CI, 1.08-3.66; P < .02), C-reactive protein (OR, 2.42; CI, 1.36-4.33; P < .01), and D-dimers (OR, 3.79; CI, 2.21-6.50; P < .001) at the time of presentation were identified as the independent predictors of mortality. Cough, shortness of breath, fever/chills, gastrointestinal symptoms, and myalgia were the predominant presentation among AAs hospitalized with COVID-19 infection. Advanced age, higher body mass index, elevated serum ferritin, C-reactive protein, and D-dimers are independent predictors of mortality among hospitalized AAs with COVID-19 infection.
Keywords: blood; coronavirus; pandemics.
【저자키워드】 coronavirus, Pandemics, Blood, 【초록키워드】 COVID-19, coronavirus disease, Coronavirus disease 2019, Hospitalized, Mortality, Clinical characteristics, hospital, Infection, C-reactive protein, D-dimer, cough, abdominal pain, diarrhea, New York City, Prevalence, body mass index, COVID-19 infection, Patient, Pandemics, Community, age, D-dimers, predictor, New York, co-morbidities, gastrointestinal symptoms, Analysis, Odds ratio, independent predictors, myalgia, demographics, presenting symptoms, body mass, presenting symptom, community hospital, Shortness of breath, confidence interval, Non-survivors, Serum ferritin, median age, laboratory data, multivariate logistic regression, morbidities, advanced age, nausea, Confirmed COVID-19 infection, chills, multivariate logistic regression analysis, vomiting, retrospective cohort, survivor, Gastrointestinal symptom, died, elevated, predominant, survived, baseline, independent predictor, patients hospitalized, patients with COVID-19, were assessed, with COVID-19, 【제목키워드】 Mortality, hospital, Characteristics, clinical, Community, predictor, New York, with COVID-19,