Abstract
Objective: To analyse the correlations between olfactory psychophysical scores and the serum levels of D-dimer, C-reactive protein, ferritin, lactate dehydrogenase, procalcitonin and neutrophil-to-lymphocyte ratio in coronavirus disease 2019 patients.
Methods: Patients underwent psychophysical olfactory assessment with the Connecticut Chemosensory Clinical Research Center test, and determination of blood serum levels of the inflammatory markers D-dimer, C-reactive protein, ferritin, lactate dehydrogenase, procalcitonin and neutrophil-to-lymphocyte ratio within 10 days of the clinical onset of coronavirus disease 2019 and 60 days after.
Results: Seventy-seven patients were included in this study. D-dimer, procalcitonin, ferritin and neutrophil-to-lymphocyte ratio correlated significantly with severe coronavirus disease 2019. No significant correlations were found between baseline and 60-day Connecticut Chemosensory Clinical Research Center test scores and the inflammatory markers assessed.
Conclusion: Olfactory disturbances appear to have little prognostic value in predicting the severity of coronavirus disease 2019 compared to D-dimer, ferritin, procalcitonin and neutrophil-to-lymphocyte ratio. The lack of correlation between the severity and duration of olfactory disturbances and serum levels of inflammatory markers seems to further suggest that the pathogenetic mechanisms underlying the loss of smell in coronavirus disease 2019 patients are related to local rather than systemic inflammatory factors.
Keywords: Anosmia; C-Reactive Protein; COVID-19; Coronavirus; Ferritins; Fibrin Fragment D; Lactate Dehydrogenases; Procalcitonin; SARS-CoV; Smell.
【저자키워드】 COVID-19, coronavirus, SARS-CoV, C-reactive protein, procalcitonin, Anosmia, fibrin fragment D, Smell, ferritins, Lactate Dehydrogenases, 【초록키워드】 coronavirus disease, Coronavirus disease 2019, severity, neutrophil, inflammatory markers, C-reactive protein, D-dimer, ferritin, procalcitonin, Local, lactate dehydrogenase, inflammatory factors, Clinical research, Anosmia, Neutrophil-to-lymphocyte ratio, lymphocyte, Patient, Factors, Connecticut, Inflammatory marker, Smell, correlation, patients, mechanism, Blood, Lactate, olfactory, Loss of Smell, Prognostic value, Serum level, severe coronavirus disease, serum levels, fragment, center, correlations, FIBRIN, systemic inflammatory, lack, significantly, correlated, baseline, 【제목키워드】 Inflammatory marker, olfactory, systemic,