Abstract
Background: Endothelial dysfunction, a major complication of SARS-CoV-2 infectionplaying a key-role in multi-organ damage, carries high risk of mortality.
Aim: To investigate the potential role of Mid-Regional pro-Adrenomedullin (MR-proADM) in detecting endothelial damage with a view to stratifying the risk of adverse events (length of stay, death, admission in Intensive Care Unit) and/or disease resolution.
Materials and methods: In 135 consecutive patients with SARS-CoV-2 infection, MR-proADM was measured in EDTA-K2 plasma samples using B.R.A.H.M.S. KRYPTOR® COMPACT Plus method (Thermo Fisher Scientific, Hennigsdorf, Germany) RESULTS: Patients were subdivided into three groups based on their MR-proADM value (nmol/L): 1 (n = 20, MR-proADM ≤ 0.55); 2 (n = 82, 0.55 < MR-proADM ≤ 1.50); 3 (n = 33, MR-proADM > 1.50). The higher the MR-proADM value, the greater the patients’ age, the more frequent the occurrence of pneumonia, the requiring of more aggressive treatment, the longer the hospitalization and the more frequent a fatal event. Significant differences were found between the three groups for MR-proADM, White-blood cell count, Neutrophil count, D-dimer, C-reactive Protein, Procalcitonin and hs-Troponin I. At logistic regression,it was found that MR-proADM and Log 10 D-dimer were the most significant predictors of adverse events.
Conclusion: The findings made in the present study highlight the relevance of MR-proADM values in providing clinically useful information, particularly for stratifying COVID-19 patients according to the risk of a more severe form of disease and to the development of adverse events.
Keywords: Endothelial damage; Endothelitis; MR-proADM; Prognosis; SARS-CoV-2.
【저자키워드】 SARS-CoV-2, Prognosis, endothelial damage, MR-proADM, Endothelitis, 【초록키워드】 Treatment, SARS-CoV-2, Mortality, Prognosis, Hospitalization, Pneumonia, SARS-COV-2 infection, neutrophil, intensive care unit, C-reactive protein, risk, D-dimer, procalcitonin, endothelial damage, Endothelial dysfunction, adrenomedullin, adverse events, Germany, adverse event, death, Logistic regression, age, predictor, troponin I, information, disease, Admission, COVID-19 patients, MR-proADM, Endothelitis, COVID-19 patient, high risk, Multi-organ damage, dysfunction, Logistic, significant differences, plasma samples, neutrophil count, three groups, EDTA, material, cell count, Thermo Fisher Scientific, highlight, plasma sample, Occurrence, was measured, greater, the patient, clinically, Significant, three group, consecutive patient, 【제목키워드】 SARS-CoV-2, dysfunction,