Abstract
Emerging data from the management of patients with coronavirus disease 2019 (COVID-19) suggests multi-systemic involvement, including the hemopoietic system. The haematological manifestations of COVID-19 include blood count anomalies notably lymphopenia and neutrophilia which are of prognostic significance. Hyperferritinemia and elevated lactate dehydrogenase have also been associated with increased mortality. Furthermore, there is considerable evidence of a distinct coagulopathy associated with COVID-19 characterised by elevated D-dimers and an increased risk of thrombotic events. This comprehensive review summarises the latest evidence from published studies and discusses the implications of the various haematological manifestations of COVID-19 with a view to guiding clinical management and risk stratification in this rapidly evolving pandemic.
Keywords: COVID-19; D-dimer; SARS-CoV-2; blood count; coagulopathy; cytokine storm; lymphopenia.
【저자키워드】 COVID-19, SARS-CoV-2, Cytokine storm, D-dimer, Coagulopathy, lymphopenia, blood count, 【초록키워드】 coronavirus disease, Coronavirus disease 2019, Cytokine storm, pandemic, D-dimer, cytokine, lactate dehydrogenase, Coagulopathy, lymphopenia, risk stratification, management, Patient, Clinical management, prognostic, Thrombotic events, Blood, Hyperferritinemia, blood count, Lactate, Evidence, manifestation, evidence of, Anomaly, increased risk, thrombotic, increased mortality, neutrophilia, elevated lactate dehydrogenase, implication, include, elevated, with COVID-19, 【제목키워드】 manifestation,