Abstract
Introduction and objectives: Liver function tests (LFT) abnormalities are reported in up to 50% of COVID-19 patients, and metabolic comorbidities are associated with poorer outcomes. The aim of the study was to determine the prevalence of liver steatosis and fibrosis in patients with COVID-19 and their association with clinical outcomes.
Material and methods: Retrospective study in hospitalized COVID-19 patients was conducted. The risk for liver steatosis was estimated by HSI > 36, and risk for advanced liver fibrosis with APRI > 1.0, NAFLD FS > 0.675 and/or FIB-4 > 3.25. Clinical outcomes were admission to Intensive Care Unit (ICU) and mortality.
Results: Of 155 patients, 71.6% were male (n = 111), and 28.4% (n = 44) were obese. Abnormal LFT were present in 96.8% (n = 150), prevalence of steatosis was 42.6% (n = 66) and of significative liver fibrosis was 44.5% (n = 69). Liver fibrosis by FIB-4 was associated with risk of ICU admission (OR 1.74 [95%CI 1.74-2.68; p = 0.023]) and mortality (OR 6.45 [95%CI 2.01-20.83, p = 0.002]); no independent associations were found.
Conclusions: The prevalence of steatosis and significant liver fibrosis was high in COVID-19 patients but was not associated with clinical outcomes.
Keywords: COVID-19; Fibrosis; Liver; SARS-CoV-2; Steatosis.
【저자키워드】 COVID-19, SARS-CoV-2, fibrosis, liver, steatosis, 【초록키워드】 Mortality, intensive care unit, Comorbidity, fibrosis, risk, outcome, clinical outcomes, ICU, Prevalence, outcomes, Retrospective study, clinical, male, ICU admission, liver function tests, Admission, liver, patients, COVID-19 patients, association, hospitalized COVID-19 patient, liver steatosis, Liver fibrosis, COVID-19 patient, NAFLD, Liver function test, hospitalized COVID-19 patients, FIB-4, obese, material, abnormality, steatosis, independent, reported, conducted, determine, patients with COVID-19, 【제목키워드】 Infection, fibrosis, Clinical outcome, patients with SARS-CoV-2,