Abstract
Coronavirus disease 2019 (COVID-19) deteriorates suddenly primarily due to excessive inflammatory injury, and insulin-like growth factor-1 (IGF-1) is implicated in endocrine control of the immune system. However, the effect of IGF-1 levels on COVID-19 prognosis remains unknown. Using UK Biobank resource, we investigated the association between circulating IGF-1 concentrations and mortality risk (available death data updated on 07 Sep 2020) among COVID-19 patients who had pre-diagnostic serum IGF-1 measurements at baseline (2006-2010). Unconditional logistic regression was performed to estimate the odds ratio (OR) and 95% confidence intervals (CIs) of mortality. Among 1670 COVID-19 patients, 415 deaths occurred due to COVID-19. Compared to the lowest quartile of IGF-1 concentrations, the highest quartile was associated with a 41% lower risk of mortality (OR = 0.59, 95% CI 0.41-0.86, P-trend = 0.01). In the continuous model, per 1-standard deviation increment in log-transformed IGF-1 was associated with a 15% reduction in the risk (intraclass correlation coefficients corrected OR = 0.85, 95% CI 0.73-0.99). The association was largely consistent in the various stratified and sensitivity analyses. In conclusion, our data suggest that higher IGF-1 concentrations are associated with a lower risk of COVID-19 mortality. Further studies are required to determine whether and how targeting IGF-1 pathway might improve COVID-19 prognosis.
Keywords: COVID-19; Coronavirus infection; IGF-1; Mortality; SARS-CoV-2; UK biobank.
【저자키워드】 COVID-19, SARS-CoV-2, Coronavirus infection, Mortality, UK biobank, IGF-1, 【초록키워드】 coronavirus disease, Coronavirus infection, Coronavirus disease 2019, coronavirus, Prognosis, UK biobank, risk, immune system, serum, death, pathway, Logistic regression, resource, insulin, IGF-1, COVID-19 patients, association, COVID-19 prognosis, mortality risk, Concentration, Inflammatory, Endocrine, Injury, COVID-19 mortality, Odds ratio, COVID-19 patient, insulin-like growth factor, 95% CI, 95% confidence interval, Sensitivity analyses, lower risk, circulating, growth factor, correlation coefficient, deviation, quartile, concentrations, insulin-like growth factor-1, lowest, IMPROVE, highest, occurred, investigated, required, was performed, determine, reduction in, implicated, stratified, baseline, CIs, deteriorate, log-transformed, 【제목키워드】 Concentration, circulating, risk of COVID-19,