Abstract
Objectives: Previous observational studies have suggested that increased cardiac markers are commonly found in COVID-19. This study aimed to determine the relationship between several cardiac markers and the severity/mortality of COVID-19 patients.
Methods: Several cardiac markers were analysed in this meta-analysis. RevMan 5.4 was used to provide pooled estimates for standardised mean difference (SMD) with 95% confidence intervals.
Results: Twenty-nine clinical studies were included in this meta-analysis. Significantly higher CK-MB (0.64, 95% CI = 0.19-1.09), PCT (0.47, 95% CI = 0.26-0.68), NT-proBNP (1.90, 95% CI = 1.63-2.17), BNP (1.86, 95% CI = 1.63-2.09), and d-dimer (1.30, 95% CI = 0.91-1.69) were found in severe compared with non-severe COVID-19. Significantly higher CK-MB (3.84, 95% CI = 0.62-7.05), PCT (1.49, 95% CI = 0.86-2.13), NT-proBNP (4.66, 95% CI = 2.42-6.91), BNP (1.96, 95% CI = 0.78-3.14), troponin (1.64 (95% CI = 0.83-2.45), and d-dimer (2.72, 95% CI = 2.14-3.29) were found in those who died from compared with survivors of COVID-19.
Conclusions: High CK-MB, PCT, NT-proBNP, BNP, and d-dimer could be predictive markers for severity of COVID-19, while high CK-MB, PCT, NT-proBNP, BNP, troponin, and d-dimer could be predictive markers for survival of COVID-19 patients.
Keywords: COVID-19; Cardiac marker; Mortality; Severity.
【저자키워드】 COVID-19, Mortality, severity, cardiac marker, 【초록키워드】 Meta-analysis, D-dimer, troponin, observational studies, observational study, survival, severity of COVID-19, Clinical studies, estimate, NT-proBNP, COVID-19 patients, BNP, marker, clinical study, cardiac, Predictive, Confidence intervals, CK-MB, 95% CI, dimer, mean difference, survivor, SMD, PCT, was used, died, analysed, determine, suggested, 【제목키워드】 severity, Predictive, Factor,