Abstract
Objectives: Olfactory and gustatory dysfunction (OD/GD) are now recognized as typical symptoms of COVID-19 infection. However, their pathogenesis remains unclear and no clear prognostic factors have been identified. We have analyzed a cohort of mild/moderate hospitalized patients to identify possible clinical or immunological predictors of recovery from OD/GD.
Methods: Clinical and biological parameters were reviewed along with associated comorbidities. Chemosensory Complaint Score was administered on admission and 30 days after the first negative swab. Unpaired Wilcoxon and chi-squared tests were used to compare the variables in the patients who recovered versus those who did not.
Results: From a cohort of 119 hospitalized patients, 43 (36%) reported OD/GD on admission. 60.6% had a full recovery from OD and 69.2% from GD. Only the concentration of IL-10 on admission emerged as significantly associated with recovery of taste (p = 0.041) while allergic respiratory disease was more prevalent in the group who did not recover from OD (p = 0.049) and GD (p = 0.007).
Conclusion: These findings suggest that COVID-19 associated OD/GD is an inflammatory-mediated condition and that clinical and immunological parameters could predict the evolution of these symptoms.
Keywords: COVID-19; Interleukin 10; Prognosis; Recovery; Smell; Taste.
【저자키워드】 COVID-19, Prognosis, recovery, Smell, Taste, Interleukin 10, 【초록키워드】 Evolution, Pathogenesis, Prognosis, Comorbidities, hospitalized patients, Cohort, interleukin, COVID-19 infection, clinical, Swab, predictor, Taste, IL-10, respiratory, Admission, predict, score, Concentration, olfactory, Prognostic factor, on admission, dysfunction, Gustatory, typical symptoms, these symptoms, full recovery, Chi-squared tests, olfactory and gustatory dysfunction, variable, Administered, immunological, prevalent, complaint, allergic respiratory disease, analyzed, identify, significantly, reported, the patient, were used, hospitalized patient, biological parameter, immunological parameter, typical symptom, 【제목키워드】 prognostic, dysfunction, chemosensory,