Abstract
SARS-CoV-2 in COVID-19 triggers abnormalities in coagulation parameters that can contribute to thrombosis. The goals of this research were to determine the levels of fibrinogen, D-dimer and FDP in COVID-19 patients. Following a systematic study, among 1198 articles, 35 studies were included in the meta-analysis of fibrinogen levels in both severe and non-severe groups. The funnel plot, Egger’s regression asymmetry test, and Begg’s test used to measure the bias of publications. All meta-analysis performed by comprehensive meta-analysis version 2 (CMA2). The pooled findings of fibrinogen levels revealed a significant rise in fibrinogen levels in severe COVID-19 than non-severe patients with COVID-19. The D-dimer and FDP levels were significantly higher in severe patients than non-severe patients with COVID-19 were. The levels of fibrinogen, D-dimer, and FDP have increased significantly in ICU patients compared to non-ICU patients. Although, levels of clotting parameters do not always correlate with the severity of disease, these findings showed the diagnostic importance for fibrinogen, D-dimer, and FDP in COVID-19. The presence of a continuous rise in serial measurements of fibrinogen, D-dimer, and FDP may predict that patients with COVID-19 may become critically ill.
Keywords: COVID-19; D-dimer; FDP; SARS-CoV-2; fibrinogen.
【저자키워드】 COVID-19, SARS-CoV-2, D-dimer, FDP, fibrinogen., 【초록키워드】 Meta-analysis, thrombosis, severe COVID-19, diagnostic, D-dimer, Coagulation, Critically ill, Research, fibrinogen, ICU Patients, Severity of disease, Severe patient, predict, COVID-19 patients, Trigger, triggers, severe patients, Fibrinogen levels, non-ICU, Abnormalities, non-severe patients, non-ICU patients, Coagulation parameters, funnel plot, abnormality, parameter, articles, ICU patient, CMA2, performed, significantly, determine, contribute, significantly higher, groups, coagulation parameter, Egger, fibrinogen level, non-severe patient, patients with COVID-19, with COVID-19, 【제목키워드】 review, fibrinogen, System, Level, Hemostatic,