Abstract
Introduction: Rise of central cytokines resulting from infections produces neuronal changes. Covid-19 allows the study of depressive symptoms in sustained stress and its relationship with molecular mechanisms.
Objectives: To assess correlation between IL-6, IL-1β and TNF-α and depressive symptoms. Characterize the depressive symptoms present.
Methods: Observational study. Patients admitted for Covid-19 older than 60 years with a interleukin determination were included. The Yesavage Geriatric Depression Scale (GDS) was used, associating each item with a neurotransmitter.
Results: 27 patients included. We did not find correlation between IL-6 levels and the GDS scale score (rho=0.204; 95% CI -0.192 to 0.543); with IL-1β levels (rho=-0.126; 95% CI -0.490 to 0.276); nor of TNF-α (rho=-0.033; 95% CI -0.416 to 0.360). 3 patients (11.1%) presented score compatible with depressive disorder. It was associated with a deficiency of noradrenaline and serotonin.
Conclusions: We found no correlation between the levels of IL-6, IL-1β, and TNF-α with the GDS score. Depressive symptomatology is similar to vascular depressions.
Keywords: Covid-19; Depresión; Depression; IL-1β; IL-6; TNF-α; Vascular.
【저자키워드】 COVID-19, Depression, IL-6, TNF-α, Depresión, IL-1β, Vascular, 【초록키워드】 Cytokines, Stress, IL-6, Infection, cytokine, observational study, Depressive symptoms, interleukin, Patient, scale, correlation, TNF-α, IL-1β, depressive disorder, IL-6 levels, changes, deficiency, Serotonin, Older, Vascular, noradrenaline, 95% CI, molecular mechanisms, no correlation, depressive, disorder, depressive symptom, neurotransmitter, resulting, was used, sustained, IL-6 level, neuronal, 【제목키워드】 interleukin 6, Patient, affected,