Abstract
The coronavirus disease 2019 (COVID-19) pandemic remains an unbeaten enemy. Unfortunately, no targeted treatment option is available. Patients with type 2 diabetes mellitus (T2DM) have increased odds for severe or fatal disease, as demonstrated in recent observational studies. There is an ongoing discussion regarding the impact of different antidiabetic drug classes on outcomes of interest among affected subjects. Dipeptidyl peptidase-4 (DPP-4) inhibitors have been placed at the epicenter, since the DPP-4 enzyme seems to be implicated in the disease pathogenesis. Herein we present an updated meta-analysis of observational studies addressing the risk of COVID-19 death among patients with T2DM on prior DPP-4 inhibitor treatment. We pooled data from 10 observational studies, showing that DPP-4 inhibitors produce a non-significant decrease in the risk for COVID-19-related death. However, when administered in the inpatient setting, DPP-4 inhibitors decrease the risk for COVID-19-related death by 50%. Ongoing randomized controlled trials will shed further light.
Keywords: COVID-19; Diabetes mellitus, type 2; Dipeptidyl-peptidase IV inhibitors; Mortality.
【저자키워드】 COVID-19, Mortality, Diabetes mellitus, type 2, Dipeptidyl-peptidase IV inhibitors, 【초록키워드】 Randomized controlled trial, Treatment, coronavirus disease, Meta-analysis, Coronavirus disease 2019, pandemic, Pathogenesis, Diabetes Mellitus, Type 2 diabetes mellitus, risk, diabetes, outcome, observational studies, observational study, Patient, death, inhibitor, disease pathogenesis, antidiabetic drug, enzyme, epicenter, COVID-19-related death, dipeptidyl peptidase, fatal disease, Administered, risk of COVID-19, decrease, affected, the disease, subjects, demonstrated, implicated, type 2 diabete, 【제목키워드】 Type,