Abstract
Immunorelevant genes are among the most probable modulators of coronavirus disease 2019 (COVID-19) progression and prognosis. However, in the few months of the pandemic, data generated on host genetics has been scarce. The present study retrieved data sets of HLA-B alleles, KIR genes and functional single nucleotide polymorphisms (SNPs) in cytokines related to COVID-19 cytokine storm from two publicly available databases: Allele Frequency Net Database and Ensembl, and correlated these frequency data with Case Fatality Rate (CFR) and Daily Death Rates (DDR) across countries. Correlations of eight HLA-B alleles and polymorphisms in three cytokine genes (IL6, IL10, and IL12B) were observed and were mainly associated with DDR. Additionally, HLA-B correlations suggest that differences in allele affinities to SARS-CoV-2 peptides are also associated with DDR. These results may provide rationale for future host genetic marker surveys on COVID-19.
Keywords: COVID-19; Cytokine polymorphisms; HLA-B; KIR.
【저자키워드】 COVID-19, Cytokine polymorphisms, HLA-B, KIR., 【초록키워드】 coronavirus disease, Coronavirus disease 2019, pandemic, Cytokines, Prognosis, host genetics, SNPs, polymorphism, IL6, cytokine, progression, SARS-CoV-2 peptides, Polymorphisms, Single nucleotide polymorphism, Case fatality rate, peptides, KIR, correlation, CFR, affinity, HLA-B, nucleotide, Frequency, data set, COVID-19 cytokine storm, rationale, KIR gene, KIR genes, correlations, allele, IL10, IL12B, Ensembl, Host, Daily, HLA-B alleles, genetic marker, Rate, eight, functional, correlated, DDR, HLA-B allele, retrieved, SARS-CoV-2 peptide, 【제목키워드】 marker,