Abstract
Coronavirus Disease 2019 (COVID-19) is a pandemic disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The clinical spectrum of COVID-19 is broad and varies from mild to severe forms complicated by acute respiratory distress and death. This heterogeneity might reflect the ability of the host immune system to interact with SARS-CoV2 or the characteristics of the virus itself in terms of loads or persistence. Information on this issue might derive from interventional studies. However, results from high-quality trials are scarce. Here we evaluate the level of evidence of available published interventional studies, with a focus on randomised controlled trials and the efficacy of therapies on clinical outcomes. Moreover, we present data on a large cohort of well-characterized patients hospitalized at a single University Hospital in Milano (Italy), correlating viral clearance with clinical and biochemical features of patients.
Keywords: COVID-19; Pharmacology; SARS-CoV-2; Viral clearance kinetics.
【저자키워드】 COVID-19, SARS-CoV-2, Pharmacology, Viral clearance kinetics., 【초록키워드】 coronavirus disease, Coronavirus disease 2019, Efficacy, coronavirus, randomised controlled trial, SARS-CoV2, therapy, Trial, Pharmacology, Italy, severe acute respiratory syndrome Coronavirus, virus, heterogeneity, viral clearance, clinical outcomes, Viral, Characteristics, persistence, death, Mild, Randomised controlled trials, large cohort, respiratory, university, patients, acute respiratory distress, Evidence, evidence of, focus, respiratory distress, acute respiratory syndrome, biochemical, acute respiratory syndrome coronavirus, acute respiratory syndrome coronavirus 2, host immune system, pandemic disease, clearance, feature, evaluate, caused, form, patients hospitalized, 【제목키워드】 Viral,