Abstract
The ongoing global pandemic of COVID-19 poses unprecedented public health risks for governments and societies around the world, which have been exacerbated by the emergence of SARS-CoV-2 variants. Pharmaceutical interventions with high antiviral efficacy are expected to delay and contain the COVID-19 pandemic. Molnupiravir, as an oral antiviral prodrug, is active against SARS-CoV-2 and is now (23 February 2022) one of the seven widely-used coronavirus treatments. To estimate its antiviral efficacy of Molnupiravir, we built a granular mathematical within-host model. We find that the antiviral efficacy of Molnupiravir to stop the growth of the virus is 0.56 (95% CI: 0.49, 0.64), which could inhibit 56% of the replication of infected cells per day. There has been good progress in developing high-efficacy antiviral drugs that rapidly reduce viral load and may also reduce the infectiousness of treated cases if administered as early as possible.
Keywords: COVID-19; Molnupiravir; SARS-CoV-2; antiviral efficacy.
【저자키워드】 COVID-19, SARS-CoV-2, molnupiravir, antiviral efficacy., 【초록키워드】 public health, coronavirus, Antiviral, molnupiravir, COVID-19 pandemic, antiviral drugs, risk, Intervention, virus, antiviral drug, Replication, global pandemic, SARS-CoV-2 variants, Viral load, infectiousness, antiviral efficacy, Government, 95% CI, growth, infected cells, pharmaceutical, infected cell, Pharmaceutical interventions, Administered, Seven, granular, inhibit, exacerbated, treated, per day, active against, reduce, expected, mathematical, 【제목키워드】 molnupiravir,