Abstract
The management of SARS-CoV-2 has not yet been clearly determined and is based on potential therapies evaluated during the SARS-CoV and MERS-CoV outbreaks. An emerging potential therapeutic approach currently being evaluated in numerous clinical trials is the remdesivir agent, which acts on COVID-19 by interfering with key steps in the virus replication cycle. It is considered a therapeutic option to be evaluated against COVID-19, based on data on its in vitro and in vivo activity against MERS-CoV and SARS-CoV coronaviruses. In this work, we provide an overview of remdesivir’s discovery, mechanism of action, and the current studies exploring its clinical effectiveness. Recommendations for its use against COVID-19 infection are also summarized.
Keywords: COVID-19; Clinical tests; Remdesivir.
【저자키워드】 COVID-19, Remdesivir, Clinical tests, 【초록키워드】 SARS-CoV-2, Coronaviruses, clinical trial, SARS-CoV, Remdesivir, in vitro, MERS, potential therapies, MERS-CoV, Outbreaks, COVID-19 infection, clinical, management, virus replication, clinical effectiveness, in vivo, mechanism of action, mechanism, Clinical tests, Therapeutic approach, therapeutic option, potential therapy, evaluated, 【제목키워드】 knowledge, GS-5734, favor, recent,