Abstract
During the last two years following the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, development of potent antiviral drugs and vaccines has been a global health priority. In this context, the understanding of virus pathophysiology, the identification of associated therapeutic targets, and the screening of potential effective compounds have been indispensable advancements. It was therefore of primary importance to develop experimental models that recapitulate the aspects of the human disease in the best way possible. This article reviews the information concerning available SARS-CoV-2 preclinical models during that time, including cell-based approaches and animal models. We discuss their evolution, their advantages, and drawbacks, as well as their relevance to drug effectiveness evaluation.
Keywords: COVID-19; SARS-CoV-2; animal model; cell model; drug.
【저자키워드】 COVID-19, SARS-CoV-2, animal model, cell model, drug., 【초록키워드】 Evolution, Vaccine, coronavirus, pandemic, antiviral drugs, animal model, drug, animal models, severe acute respiratory syndrome Coronavirus, virus, antiviral drug, Health, pathophysiology, Effectiveness, information, therapeutic targets, experimental model, acute respiratory syndrome, acute respiratory syndrome coronavirus, human disease, acute respiratory syndrome coronavirus 2, Compound, experimental models, effective, Cell, develop, approach, concerning, 【제목키워드】 animal, Model,