Abstract
The COVID-19 outbreak has been devastating, with hundreds of millions of infections and millions of deaths reported worldwide. In response, the application of structure-activity relationships (SAR) upon experimentally validated inhibitors of SARS-CoV-2 main protease (M pro ) may provide an avenue for the identification of new lead compounds active against COVID-19. Upon the basis of information gleaned from a combination of reported crystal structures and the docking of experimentally validated inhibitors, four “rules” for designing potent M pro inhibitors have been proposed. The aim here is to guide medicinal chemists toward the most probable hits and to provide guidance on repurposing available structures as M pro inhibitors. Experimental examination of our own previously reported inhibitors using the four “rules” identified a potential lead compound, the cathepsin inhibitor GB111-NH 2 , that was 2.3 times more potent than SARS-CoV-2 M pro inhibitor N3 .
【초록키워드】 COVID-19, Structure, SARS-CoV-2, Infection, docking, protease, inhibitors, SARS-CoV-2 main protease, COVID-19 outbreak, death, crystal structure, inhibitor, SAR, information, Guidance, Combination, inhibitor N3, inhibitors of SARS-CoV-2, Compound, M pro, reported, active against, cathepsin inhibitor, 【제목키워드】 SARS-CoV-2,