Abstract
Measles virus (MV) is a highly contagious respiratory virus responsible for outbreaks associated with significant morbidity and mortality among children and young adults. Although safe and effective measles vaccines are available, the COVID-19 pandemic has resulted in vaccination coverage gaps that may lead to the resurgence of measles when restrictions are lifted. This puts individuals who cannot be vaccinated, such as young infants and immunocompromised individuals, at risk. Therapeutic interventions are complicated by the long incubation time of measles, resulting in a narrow treatment window. At present, the only available WHO-advised option is treatment with intravenous immunoglobulins, although this is not approved as standard of care. Antivirals against measles may contribute to intervention strategies to limit the impact of future outbreaks. Here, we review previously described antivirals and antiviral assays, evaluate the antiviral efficacy of a number of compounds to inhibit MV dissemination in vitro, and discuss potential application in specific target populations. We conclude that broadly reactive antivirals could strengthen existing intervention strategies to limit the impact of measles outbreaks.
Keywords: antiviral; antiviral assay; fusion inhibitory peptide; measles; measles virus; pandemic response box; remdesivir.
【저자키워드】 Antiviral, Remdesivir, antiviral assay, fusion inhibitory peptide, measles, measles virus, pandemic response box, 【초록키워드】 Treatment, Vaccine, vaccination, pandemic, Antiviral, children, COVID-19 pandemic, immunoglobulins, peptide, Remdesivir, risk, Intervention, in vitro, Infant, Adults, Outbreaks, Coverage, respiratory virus, outbreak, Antiviral assays, antiviral efficacy, morbidity and mortality, dissemination, measles, measles virus, Safe, intravenous, can not, Standard of care, immunocompromised individuals, individual, Compound, therapeutic interventions, present, contagious, resurgence, inhibitory, populations, effective, limit, reactive, responsible, resulting, described, evaluate, inhibit, approved, contribute, lifted, 【제목키워드】 repurposing, Screening, measles virus, Compound, Measle,