Abstract
Inhibitors of viral cell entry based on poly(styrene sulfonate) and its core-shell nanoformulations based on gold nanoparticles are investigated against a panel of viruses, including clinical isolates of SARS-CoV-2. Macromolecular inhibitors are shown to exhibit the highly sought-after broad-spectrum antiviral activity, which covers most analyzed enveloped viruses and all of the variants of concern for SARS-CoV-2 tested. The inhibitory activity is quantified in vitro in appropriate cell culture models and for respiratory viral pathogens (respiratory syncytial virus and SARS-CoV-2) in mice. Results of this study comprise a significant step along the translational path of macromolecular inhibitors of virus cell entry, specifically against enveloped respiratory viruses.
Keywords: SARS-CoV-2; broad-spectrum antivirals; entry inhibitors; in vivo; macromolecules; polyanions; respiratory syncytial virus (RSV).
【저자키워드】 SARS-CoV-2, polyanions, broad-spectrum antivirals, in vivo, entry inhibitors, macromolecules, respiratory syncytial virus (RSV)., 【초록키워드】 viruses, variants of concern, in vitro, antiviral activity, virus, inhibitors, variants, respiratory viruses, pathogen, respiratory syncytial virus, RSV, mice, Cell culture, gold, broad-spectrum antivirals, Pathogens, clinical isolates, entry inhibitors, inhibitor, Gold nanoparticle, cell entry, inhibitory activity, viral cell, isolate, respiratory viral, STYRENE, sulfonate, Result, shown, tested, analyzed, investigated, macromolecular, translational, quantified, 【제목키워드】 activity,