Abstract
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing the coronavirus disease-19 (COVID-19) is still challenging healthcare systems and societies worldwide. While vaccines are available, therapeutic strategies are developing and need to be adapted to each patient. Many clinical approaches focus on the repurposing of approved therapeutics against other diseases. However, the efficacy of these compounds on viral infection or even harmful secondary effects in the context of SARS-CoV-2 infection are sparsely investigated. Similarly, adverse effects of commonly used therapeutics against lifestyle diseases have not been studied in detail. Using mono cell culture systems and a more complex chip model, we investigated the effects of the acetylsalicylic acid (ASA) salt D,L-lysine-acetylsalicylate + glycine (LASAG) on SARS-CoV-2 infection in vitro. ASA is commonly known as Aspirin ® and is one of the most frequently used medications worldwide. Our data indicate an inhibitory effect of LASAG on SARS-CoV-2 replication and SARS-CoV-2-induced expression of pro-inflammatory cytokines and coagulation factors. Remarkably, our data point to an additive effect of the combination of LASAG and the antiviral acting drug remdesivir on SARS-CoV-2 replication in vitro.
Keywords: COVID-19; LASAG; SARS-CoV-2; chip model; pro-inflammation; remdesivir.
【저자키워드】 COVID-19, SARS-CoV-2, Remdesivir, LASAG, chip model, pro-inflammation, 【초록키워드】 coronavirus disease, viral infection, Efficacy, Vaccine, coronavirus, Cytokines, Antiviral, SARS-COV-2 infection, Remdesivir, repurposing, in vitro, medications, severe acute respiratory syndrome Coronavirus, adverse effects, Coronavirus disease-19, Patient, Therapeutic strategies, Aspirin, pro-inflammatory cytokines, Coagulation factors, medication, disease, expression, SARS-CoV-2 replication, therapeutic strategy, Combination, Acetylsalicylic acid, Healthcare system, salt, glycine, additive effect, Healthcare systems, adverse effect, acute respiratory syndrome, other diseases, acute respiratory syndrome coronavirus, acute respiratory syndrome coronavirus 2, complex, inhibitory effect, pro-inflammatory cytokine, these compounds, while, Effect, approach, L-lysine, investigated, approved, these compound, acting, cell culture system, 【제목키워드】 show, Effect, Additive,