Abstract
Introduction: COVID-19, a dreadful pandemic that has impacted human life like no other pathogenic invasion, has claimed the lives of over 100 million people. The need for effective treatment strategies is still a subject of intense research considering the rapidly evolving genome and continental diversity. Indomethacin is administered mostly as co-treatment for affected patients as a non-steroidal anti-inflammatory drug (NSAID). However, the underlying mechanism of action is unresolved. This study explores the basal mechanism of indomethacin and potency in alleviating the damage caused by SARS-CoV-2 and discusses the experimental and clinical efficacy in recent studies.
Areas covered: The literature search and system biology-based network formation were employed to describe the potent effects and risks associated with indomethacin in in-vitro, in-vivo, and clinical studies. This study also highlights the plausible mechanism of antiviral action of indomethacin with its apparent viral protein targets. The SARS-CoV-2 protein, the interacting host proteins, and the effect of indomethacin on this interactome as a standalone treatment or as part of a co-therapy strategy are particularly emphasized using network modeling.
Expert opinion: Indomethacin has demonstrated excellent clinical endpoint characteristics in several studies, and we recommend that it be utilized in the treatment of mild-to-moderate COVID patients.
Keywords: COVID-19; NSAID; anti-viral; genetic interaction network; indomethacin; mechanism of action; protein–protein interaction.
【저자키워드】 COVID-19, Anti-viral, indomethacin, mechanism of action, NSAID, genetic interaction network, protein–protein interaction., 【초록키워드】 Treatment, SARS-CoV-2, pandemic, Genome, Genetic, risk, Anti-viral, Characteristics, Research, Patient, Clinical studies, genetic interaction, indomethacin, targets, mechanism, Protein–protein interaction, host proteins, Clinical efficacy, Interaction, treatment strategy, Invasion, Mild-to-moderate, In-vitro, Viral protein, Endpoint, subject, damage, potency, pathogenic, anti-inflammatory drug, antiviral action, Covid patients, SARS-CoV-2 protein, Administered, Effect, expert, effective, highlight, standalone treatment, affected, caused, demonstrated, Area, impacted, claimed, 【제목키워드】 Antiviral, host-pathogen interaction, mechanism, exploratory study,