Abstract
Translation of in vitro antiviral activity to the in vivo setting is crucial to identify potentially effective dosing regimens of hydroxychloroquine. In vitro 50%/90% maximal effective concentration values for hydroxychloroquine should be compared to the in vivo free extracellular tissue concentration, which is similar to the free plasma hydroxychloroquine concentration.
Keywords: COVID-19; SARS-CoV-2; antiviral activity; hydroxychloroquine.
All Keywords
【저자키워드】 COVID-19, SARS-CoV-2, Hydroxychloroquine, antiviral activity, 【초록키워드】 Hydroxychloroquine, Antiviral, translation, in vitro, antiviral activity, plasma, in vivo, Concentration, tissue, effective, Extracellular, identify, dosing regimen, 【제목키워드】 Hydroxychloroquine, prediction, antiviral activity, activity, step, treating,
【저자키워드】 COVID-19, SARS-CoV-2, Hydroxychloroquine, antiviral activity, 【초록키워드】 Hydroxychloroquine, Antiviral, translation, in vitro, antiviral activity, plasma, in vivo, Concentration, tissue, effective, Extracellular, identify, dosing regimen, 【제목키워드】 Hydroxychloroquine, prediction, antiviral activity, activity, step, treating,
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시험관 내 항바이러스 활성을 생체 내 설정으로 변환하는 것은 하이드록시클로로퀸의 잠재적으로 효과적인 투여 요법을 확인하는 데 중요합니다. 히드록시클로로퀸의 시험관 내 50%/90% 최대 유효 농도 값은 유리 혈장 히드록시클로로퀸 농도와 유사한 생체 내 유리 세포외 조직 농도와 비교해야 합니다.
{{ 키워드: }} 코로나19; 사스 코로나바이러스 2; 항바이러스 활성; 하이드록시클로로퀸.