A 30-year-old homosexual man with the acquired immune deficiency syndrome and a recent history of zoster involving the mandibular division of the right trigeminal nerve was found at autopsy to have a predominantly demyelinating lesion restricted to the ipsilateral spinal trigeminal tract and nucleus. Cowdry A inclusions were readily apparent in the nuclei of numerous glia and isolated neurons, and inclusion-bearing cells were immunoreactive with an antiserum to the varicella zoster virus (VZV). This represents the first demonstration that zoster-associated trigeminal encephalitis is the result of brainstem invasion by VZV. The restricted topography of this lesion implicates axonal transport in its pathogenesis.
Bulbar encephalitis complicating trigeminal zoster in the acquired immune deficiency syndrome
후천성 면역 결핍 증후군에서 삼차신경 대상포진을 동반한 구뇌염
[Category] 대상포진, 수두,
[Article Type] Case Reports
[Source] pubmed
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