Abstract
Since the outbreak of COVID-19, one of the strategies used to search for new drugs has been to find inhibitors of the main protease (Mpro) of the virus SARS-CoV-2. Initially, previously reported inhibitors of related proteases such as the main proteases of SARS-CoV and MERS-CoV were tested. A huge effort was then carried out by the scientific community to design, synthesize and test new small molecules acting as inactivators of SARS-CoV-2 Mpro. From the chemical structure view, these compounds can be classified into two main groups: one corresponds to modified peptides displaying an adequate sequence for high affinity and a reactive warhead; and the second is a diverse group including chemical compounds that do not have a peptide framework. Although a drug including a SARS-CoV-2 main protease inhibitor has already been commercialized, denoting the importance of this field, more compounds have been demonstrated to be promising potent inhibitors as potential antiviral drugs.
Keywords: COVID-19; Mpro; inhibitors; main protease.
【저자키워드】 COVID-19, main protease, inhibitors, MPro, 【초록키워드】 SARS-CoV-2, SARS-CoV, antiviral drugs, peptide, drug, protease, MERS, virus, MERS-CoV, inhibitors, SARS-CoV-2 main protease, MPro, SARS-CoV-2 Mpro, outbreak, peptides, Scientific community, small molecule, Proteases, inhibitor, Compound, sequence, high affinity, effort, these compounds, Chemical structure, reactive, tested, carried, reported, demonstrated, these compound, displaying, acting, Initially, 【제목키워드】 development, advance,